No Interaction Between Childhood Maltreatment and Serotonin Transporter Gene in Recurrent Major Depressive Disorder: A Clinical Sample

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Ozcurumez G., Yurdakul H. T., Terzi Y., Direk N., EŞSİZOĞLU A., Sahin F.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.56, no.2, pp.110-114, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.29399/npa.23325
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.110-114
  • Keywords: Recurrent depression, childhood maltreatment, 5-HTTLPR, LIFE EVENTS, POLYMORPHISM, ABUSE, ASSOCIATION, MODERATION, 5-HTTLPR, STRESS, TRAUMA, ADULTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Introduction: There is inconsistent evidence of interaction between childhood adversities and a serotonin transporter promoter polymorphism (5- HTTLPR) in depression. It is hypothesized that genetic sensitivity to stress could be more specific to recurrent major depressive disorder (MDD). The aim of the study is to replicate a recent study which provided preliminary evidence of interaction between severity of childhood maltreatment and the 5-HTTLPR polymorphism in recurrent MDD.